Preventive effects of selenium against cypermethrin induced haematological toxicity in Sprague-Dawley rats

Purpose: Cypermethrin (class II) belongs to pyrethroid insecticides which have been in wide use control various pests including moth of cotton, fruit and vegetable crops. This study was aimed investigate the effects cypermethrin on haematology female rats their modulation by co-administration sodium selenite. Methodology: Four equal groups were made (n=20). Group 1 received ml corn oil, 2 administered 55 mg/kg/b.w cypermethrin, 3 provided with ppm selenite 4 given both Haematological analysis blood samples performed employing Sesmex Kx-21 (Japan). Results: Red cell (RBC) count, haemoglobin concentration (Hb) hematocrit (Hct) significantly reduced (P<0.05) due treatment indicates that suffering from anaemia. While, rest hematological parameters i.e. platelet count (PLT), number lymphocytes, white (WBC) larger ratio (P-LCR), RBC distribution width (RDW), mean volume (MPV), (PDW), lymphocyte percentage (LYM), corpuscular (MCHC), (MCH) (MCV) non-significantly affected. Selenium coadministration found restore levels above-mentioned those group. Conclusion: Hence, it can be concluded this administration cause alterations rats. Co-administration selenium protection against toxicity some extent.